For most applications, your success is based upon using an Aerator Device. So the short answer is Yes, you should be using one.
Why?
Simply put, an aerator or bubbler box allows the Chlorine Dioxide (ClO2) molecule to be properly dispersed. It attaches to the bubbles and can then be circulated around to penetrate and deal with the odor-causing elements. The central air, A/C or fans allow the ClO2 bubbles to move around the space and do their job.
You can purchase an appropriate aerator device from us, or find one at common department stores similar to Walmart. Most Walmart stores offer one of these devices and it make go by the name of a "bubbler" device or "bubbler box."